Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11264103 | 0.82 | ALDH1A1 (0.52) | NPC1RAB9AMAPTHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11264101 | 0.80 | ALDH1A1 (0.51) | NPC1RAB9AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL11656026 | 0.79 | NPC1 (0.47) | NPC1RAB9AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL6516769 | 0.76 | RAB9A (0.45) | NPC1RAB9AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL7399499 | 0.75 | HPGD (0.41) | NPC1RAB9AMAPTHPGDSMN1; SMN2 | |
| Ethylamine SCHEMBL6158093 | 0.75 | NPC1 (0.58) | NPC1RAB9AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL1067241 | 0.74 | ALDH1A1 (0.42) | NPC1RAB9AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL10712470 | 0.74 | BACE1 (0.47) | NPC1RAB9AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL938200 | 0.74 | RAB9A (0.47) | NPC1RAB9AMAPTHPGDSMN1; SMN2 | |
| SCHEMBL3316024 | 0.72 | KMT2A (0.50) | MAPTHPGDSMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4360681-A | ANTILIPOLYTIC OR DIETETIC AGENT, INTERMEDIATE FOR BIOTIN | HOFFMANN-LA ROCHE INC. (US) | 1982-11-23 | — | — | US | disclosed |
| US-4299968-A | CHEMICAL INTERMEDIATES FOR BIOTIN AND BLOOD LIPID LOWERING AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-11-10 | — | — | US | disclosed |