Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.67 |
| ▸ | TP53 | P04637 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.64 |
| ▸ | NPC1 | O15118 | 9/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.62 |
| ▸ | RAB9A | P51151 | 8/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.60 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.60 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.60 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.60 |
| ▸ | KCNK4 | Q9NYG8 | 1/20 | 0.60 |
| ▸ | APP | P05067 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1071608 | 0.96 | MAPT (0.67) | MAPTTP53SMN1; SMN2NPC1KDM4E | |
| SCHEMBL2252511 | 0.92 | MAPT (0.74) | MAPTTP53SMN1; SMN2NPC1KDM4E | |
| SCHEMBL12980051 | 0.87 | MAPT (0.67) | MAPTTP53SMN1; SMN2NPC1KDM4E | |
| SCHEMBL6227082 | 0.84 | MAPT (0.76) | MAPTTP53SMN1; SMN2NPC1KDM4E | |
| SCHEMBL1984153 | 0.84 | MMP2 (0.74) | MAPTTP53SMN1; SMN2NPC1KDM4E | |
| SCHEMBL6481372 | 0.84 | MAPT (0.63) | MAPTTP53SMN1; SMN2NPC1KDM4E | |
| SCHEMBL12422004 | 0.84 | MAPT (0.63) | MAPTTP53SMN1; SMN2NPC1KDM4E | |
| SCHEMBL2193235 | 0.83 | MAPT (0.73) | MAPTTP53SMN1; SMN2NPC1KDM4E | |
| SCHEMBL3932997 | 0.82 | MAPT (0.78) | MAPTTP53SMN1; SMN2NPC1KDM4E | |
| SCHEMBL12422006 | 0.82 | APP (0.63) | MAPTTP53SMN1; SMN2NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150150852-A1 | TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECHNOLOGIES, INC. (US) | 2015-06-04 | — | — | US | claimed |
| US-8993604-B2 | Treatment and prevention of dengue virus infections | SIGA TECHNOLOGIES, INC. (US) | 2015-03-31 | — | — | US | claimed |
| US-20120258079-A1 | Treatment and Prevention of Dengue Virus Infections | SIGA TECHNOLOGIES, INC. | 2012-10-11 | — | — | US | claimed |
| CN-102469788-A | Treatment and prevention of dengue virus infection | SIGA TECHNOLOGIES INC | 2012-05-23 | — | — | CN | claimed |
| EP-2448410-A1 | TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | Siga Technologies, Inc. (US) | 2012-05-09 | — | — | EP | claimed |
| WO-2011002635-A1 | TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECHNOLOGIES, INC. (US) | 2011-01-06 | — | — | WO | claimed |
| US-20150150852-A1 | TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECHNOLOGIES, INC. (US) | 2015-06-04 | — | — | US | disclosed |
| US-8993604-B2 | Treatment and prevention of dengue virus infections | SIGA TECHNOLOGIES, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20120258079-A1 | Treatment and Prevention of Dengue Virus Infections | SIGA TECHNOLOGIES, INC. | 2012-10-11 | — | — | US | disclosed |
| CN-102469788-A | Treatment and prevention of dengue virus infection | SIGA TECHNOLOGIES INC | 2012-05-23 | — | — | CN | disclosed |
| EP-2448410-A1 | TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | Siga Technologies, Inc. (US) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011002635-A1 | TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | SIGA TECHNOLOGIES, INC. (US) | 2011-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150150852-A1 | TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS | HAVCR2, TTPA, CHIA | MAPT 118/4885TP53 2739/4885SMN1; SMN2 814/4885 |
| US-20120258079-A1 | Treatment and Prevention of Dengue Virus Infections | HAVCR2, TTPA, CHIA | MAPT 118/4885TP53 2739/4885SMN1; SMN2 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.