Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 11/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 2/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10717419 | 0.80 | CTSK (0.52) | CTSLCTSBCTSSCTSKMEN1 | |
| SCHEMBL29931085 | 0.76 | HTT (0.54) | MAPTKLK7KLK5KEAP1NFE2L2 | |
| SCHEMBL12076369 | 0.74 | MAPT (0.52) | MAPTITGB3ITGA2BKLK7KLK5 | |
| SCHEMBL6511442 | 0.74 | MAPT (0.52) | MAPTITGB3ITGA2BKLK7KLK5 | |
| SCHEMBL10717386 | 0.73 | REN (0.53) | CTSLCTSBCTSSCTSK | |
| SCHEMBL9556048 | 0.71 | HTRA1 (0.54) | HTRA1MAPTITGB3ITGA2BKLK7 | |
| SCHEMBL8574390 | 0.71 | MAPT (0.47) | MAPTKLK7KLK5KEAP1NFE2L2 | |
| SCHEMBL8574384 | 0.71 | MAPT (0.47) | MAPTKLK7KLK5KEAP1NFE2L2 | |
| SCHEMBL9073343 | 0.70 | FOLH1 (0.52) | MAPTKLK7KLK5CTSL | |
| SCHEMBL31300270 | 0.69 | MAPT (0.52) | MAPTKLK7KLK5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210545-A2 | Phosphorous containing enzyme inhibitors | MERCK & CO. INC. (US) | 1987-02-04 | — | — | EP | disclosed |