Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA4 | P22748 | 3/20 | 0.53 |
| ▸ | CA9 | Q16790 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10731823 | 0.83 | MAPT (0.59) | ALDH1A1SMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL10716672 | 0.82 | ALDH1A1 (0.50) | CA2CA1CA4CA9ALDH1A1 | |
| SCHEMBL10716690 | 0.81 | NPSR1 (0.50) | ALDH1A1SMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL10727222 | 0.81 | MAPT (0.50) | ALDH1A1SMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL10716456 | 0.77 | PKM (0.49) | CA2CA1CA4CA9ALDH1A1 | |
| SCHEMBL10717754 | 0.75 | ALDH1A1 (0.52) | CA2CA1CA4CA9ALDH1A1 | |
| SCHEMBL10732444 | 0.74 | MAPT (0.49) | ALDH1A1SMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL10717874 | 0.72 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2LMNAKDM4EATM | |
| SCHEMBL10716660 | 0.72 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL10730945 | 0.72 | PKM (0.58) | CA2CA1CA4CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4659727-A | ANTIARTHRITIC AGENTS | MAY & BAKER LIMITED (GB) | 1987-04-21 | — | — | US | disclosed |
| EP-0174832-A2 | Ethene derivatives | MAY & BAKER LIMITED (GB) | 1986-03-19 | — | — | EP | disclosed |