Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437687 | 0.83 | ATM (0.53) | CTSKCTSSPSEN1PSEN2APH1B | |
| SCHEMBL10188332 | 0.83 | CTSK (0.51) | CTSKCTSSPSEN1PSEN2APH1B | |
| SCHEMBL22409488 | 0.79 | CTSK (0.49) | CTSKCTSSGABRB1GABRB2MAPT | |
| SCHEMBL13929428 | 0.78 | LMNA (0.58) | CTSKCTSSMAPTATM | |
| SCHEMBL13996047 | 0.78 | LMNA (0.58) | CTSKCTSSMAPTATM | |
| SCHEMBL14011507 | 0.78 | LMNA (0.58) | CTSKCTSSMAPTATM | |
| SCHEMBL90531 | 0.77 | CA1 (0.63) | CTSKCTSSCA1CA2CA7 | |
| SCHEMBL16690468 | 0.77 | CA1 (0.63) | CTSKCTSSCA1CA2CA7 | |
| SCHEMBL10684957 | 0.76 | REN (0.52) | CTSKCTSSPSEN1PSEN2APH1B | |
| SCHEMBL9282508 | 0.76 | PSEN1 (0.59) | CTSSPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4645759-A | HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1987-02-24 | — | — | US | disclosed |
| EP-0172347-A2 | Renin inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-02-26 | — | — | EP | disclosed |