Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5615956 | 0.88 | NPC1 (0.46) | NPC1RAB9APKMLMNAALDH1A1 | |
| SCHEMBL2536 | 0.83 | LMNA (0.57) | PKMLMNAALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL62534 | 0.83 | ALDH1A1 (0.59) | LMNAALDH1A1L3MBTL1MAPK1MAPT | |
| SCHEMBL9468081 | 0.82 | ALDH1A1 (0.46) | NPC1RAB9APKMLMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL27368126 | 0.81 | ALDH1A1 (0.58) | LMNAALDH1A1L3MBTL1MAPK1MAPT | |
| SCHEMBL18281071 | 0.81 | LMNA (0.51) | NPC1RAB9ALMNAALDH1A1L3MBTL1 | |
| SCHEMBL7376270 | 0.81 | LMNA (0.51) | NPC1RAB9ALMNAALDH1A1L3MBTL1 | |
| SCHEMBL28257721 | 0.79 | LMNA (0.53) | NPC1RAB9ALMNAALDH1A1L3MBTL1 | |
| SCHEMBL7372699 | 0.78 | SLC15A1 (0.49) | NPC1RAB9ALMNAALDH1A1L3MBTL1 | |
| SCHEMBL3654908 | 0.78 | LMNA (0.54) | PKMLMNAALDH1A1L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4690936-A | AMINO ACIDS, THIOESTER LINKAGE; ANGIOTENSIN INHIBITORS | UNIVERSITY OF MIAMI (US) | 1987-09-01 | — | — | US | disclosed |
| EP-0036713-B1 | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | UNIVERSITY OF MIAMI (US) | 1984-01-18 | — | — | EP | disclosed |
| EP-0036713-A2 | Angiotensin converting enzyme inhibitors | UNIVERSITY OF MIAMI (US) | 1981-09-30 | — | — | EP | disclosed |