Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 7/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 6/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.39 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10724389 | 0.82 | CYP11B1 (0.52) | CYP11B1CYP11B2TBXAS1CYP19A1MAPT | |
| SCHEMBL10727048 | 0.81 | CYP11B1 (0.50) | CYP11B1CYP11B2TBXAS1CYP19A1MAPT | |
| SCHEMBL10730627 | 0.79 | CYP11B1 (0.48) | CYP11B1CYP11B2TBXAS1CYP19A1MAPT | |
| SCHEMBL10646110 | 0.74 | CYP11B1 (0.53) | CYP11B1CYP11B2TBXAS1CYP19A1CYP1A2 | |
| SCHEMBL10724228 | 0.74 | CA12 (0.39) | MAPTCYP1A2CYP3A4CYP2D6PDE4A | |
| SCHEMBL9379475 | 0.72 | SHMT2 (0.57) | CYP11B1CYP11B2TBXAS1CYP19A1MAPT | |
| SCHEMBL11097452 | 0.71 | CYP11B1 (0.55) | CYP11B1CYP11B2TBXAS1CYP19A1MAPT | |
| SCHEMBL13907297 | 0.69 | CYP11B1 (0.68) | CYP11B1CYP11B2TBXAS1CYP19A1MAPT | |
| SCHEMBL6014889 | 0.66 | CA12 (0.71) | MAPTCYP1A2POLBCYP3A4CYP2D6 | |
| SCHEMBL10645457 | 0.65 | CYP11B1 (0.56) | CYP11B1CYP11B2TBXAS1CYP19A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112987-B1 | IMIDAZOLYLALKYLTHIENYL-TETRAHYDROPYRIDAZINES AND PROCESS FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1987-04-01 | — | — | EP | claimed |
| EP-0112987-A1 | Imidazolylalkylthienyl-tetrahydropyridazines and process for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-07-11 | — | — | EP | claimed |
| EP-0112987-B1 | IMIDAZOLYLALKYLTHIENYL-TETRAHYDROPYRIDAZINES AND PROCESS FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1987-04-01 | — | — | EP | disclosed |
| US-4643998-A | Imidazolylalkylthienyl tetrahydropyridazines and processes for their use | A. NATTERMAN & CIE GMBH (DE) | 1987-02-17 | — | — | US | disclosed |
| EP-0112987-A1 | Imidazolylalkylthienyl-tetrahydropyridazines and process for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-07-11 | — | — | EP | disclosed |