Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 10/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10727048 | 0.91 | CYP11B1 (0.50) | CYP11B1CYP11B2TBXAS1KDM4EALDH1A1 | |
| SCHEMBL10724389 | 0.87 | CYP11B1 (0.52) | CYP11B1CYP11B2TBXAS1KDM4EALDH1A1 | |
| SCHEMBL10724403 | 0.79 | CYP11B1 (0.57) | CYP11B1CYP11B2PDE4BTBXAS1KDM4E | |
| SCHEMBL10646110 | 0.74 | CYP11B1 (0.53) | CYP11B1CYP11B2PDE4BTBXAS1CYP19A1 | |
| SCHEMBL11097452 | 0.71 | CYP11B1 (0.55) | CYP11B1CYP11B2TBXAS1MAPTCYP19A1 | |
| SCHEMBL11242032 | 0.69 | PDE4B (0.51) | PDE4BALDH1A1PDE3BPDE3A | |
| SCHEMBL13907297 | 0.69 | CYP11B1 (0.68) | CYP11B1CYP11B2TBXAS1MAPTCYP19A1 | |
| SCHEMBL10646442 | 0.66 | PDE3B (0.46) | CYP11B1CYP11B2PDE4BTBXAS1CYP19A1 | |
| SCHEMBL10645457 | 0.65 | CYP11B1 (0.56) | CYP11B1CYP11B2TBXAS1MAPTCYP19A1 | |
| SCHEMBL10646151 | 0.65 | CYP11B1 (0.47) | CYP11B1CYP11B2TBXAS1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112987-B1 | IMIDAZOLYLALKYLTHIENYL-TETRAHYDROPYRIDAZINES AND PROCESS FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1987-04-01 | — | — | EP | disclosed |
| US-4643998-A | Imidazolylalkylthienyl tetrahydropyridazines and processes for their use | A. NATTERMAN & CIE GMBH (DE) | 1987-02-17 | — | — | US | disclosed |
| EP-0112987-A1 | Imidazolylalkylthienyl-tetrahydropyridazines and process for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-07-11 | — | — | EP | disclosed |