Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 6/20 | 0.58 |
| ▸ | TOP1 | P11387 | 4/20 | 0.45 |
| ▸ | CYCS | P99999 | 4/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10729176 | 0.98 | TERT (0.61) | TERTTOP1CYCSABCG2ENPP2 | |
| Bromide SCHEMBL10730446 | 0.91 | TERT (0.64) | TERTTOP1CYCSABCG2ENPP2 | |
| Bromide SCHEMBL10894063 | 0.90 | TERT (0.65) | TERTTOP1CYCSABCG2ENPP2 | |
| SCHEMBL10724268 | 0.89 | TERT (0.67) | TERTTOP1CYCSABCG2ENPP2 | |
| Bromide SCHEMBL10896967 | 0.88 | TERT (0.57) | TERTTOP1CYCSABCG2ENPP2 | |
| SCHEMBL10724808 | 0.87 | TERT (0.58) | TERTTOP1CYCSABCG2ENPP2 | |
| Hydrochloric Acid SCHEMBL19718144 | 0.86 | TERT (0.59) | TERTTOP1CYCSABCG2ENPP2 | |
| Iodide SCHEMBL10724109 | 0.84 | TERT (0.67) | TERTTOP1CYCSABCG2ENPP2 | |
| SCHEMBL10724093 | 0.83 | TERT (0.68) | TERTTOP1CYCSABCG2ENPP2 | |
| Bromide SCHEMBL10896267 | 0.79 | TERT (0.62) | TERTTOP1CYCSABCG2ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127797-B1 | LABELLED MOLECULES FOR FLUORESCENCE IMMUNOASSAYS AND PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-06-16 | — | — | EP | claimed |
| US-4614723-A | Porphyrin derivatives as fluorescent markers for immunoassays | HOFFMANN-LA ROCHE INC. (US) | 1986-09-30 | — | — | US | disclosed |