Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14339474 | 0.84 | KDM4E (0.50) | KDM4ES1PR4HSP90AA1MAPTG6PD | |
| SCHEMBL20431234 | 0.82 | AMY1A (0.39) | KDM4ES1PR4HSP90AA1MAPTG6PD | |
| SCHEMBL10731275 | 0.79 | CA1 (0.46) | KDM4EMAPTMAPK1ALDH1A1LMNA | |
| SCHEMBL6865460 | 0.76 | NQO2 (0.41) | KDM4ES1PR4HSP90AA1MAPTG6PD | |
| SCHEMBL11137781 | 0.76 | GAA (0.35) | KDM4ES1PR4HSP90AA1MAPTG6PD | |
| SCHEMBL11153759 | 0.76 | TSHR (0.39) | KDM4EMAPTMAPK1RAB9AALDH1A1 | |
| SCHEMBL53547 | 0.75 | ALDH1A1 (0.46) | KDM4ES1PR4HSP90AA1MAPTG6PD | |
| SCHEMBL30715275 | 0.75 | ALDH1A1 (0.46) | KDM4ES1PR4HSP90AA1MAPTG6PD | |
| SCHEMBL3292383 | 0.73 | MAPT (0.41) | KDM4ES1PR4HSP90AA1MAPTG6PD | |
| Hydrochloric Acid SCHEMBL11303156 | 0.71 | ALDH1A1 (0.43) | KDM4ES1PR4HSP90AA1MAPTG6PD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112110-A1 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | UNIVERSITA' DEGLISTUDI DI MILANO- BICOCCA (IT) | 2011-05-12 | — | — | US | disclosed |
| US-4672138-A | INTERMEDIATES FOR BENZO (B) THIOPHENES; HYPOTENSIVE AGENTS, DIURETICS | HOECHST ROUSSEL PHARMACEUTICALS INC. (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0050326-B1 | BENZO(B)THIOPHENES | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-01-29 | — | — | EP | disclosed |
| EP-0155981-A2 | Derivatives of alkoxythiophenol; alkoxyphenolthio carbamates | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-10-02 | — | — | EP | disclosed |
| US-4537976-A | Benzo[b]thiophenes | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-08-27 | — | — | US | disclosed |
| US-4528399-A | Benzo[b]thiophenes intermediates | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-07-09 | — | — | US | disclosed |
| US-4436748-A | HYPOTENSIVES, DIURETICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1984-03-13 | — | — | US | disclosed |
| US-4389416-A | DIURETICS | ABBOTT LABORATORIES (US) | 1983-06-21 | — | — | US | disclosed |
| EP-0050326-A2 | Benzo(b)thiophenes | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-04-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112110-A1 | ANTIPROLIFERATIVE COMPOUNDS AND THERAPEUTIC USES THEREOF | ABL1, MKI67, BCR | KDM4E 2473/4885S1PR4 3476/4885HSP90AA1 512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.