SCHEMBL10729640

SCHEMBL10729640

CN(C(=O)C1(Cl)CC1(Cl)Cl)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.45
KMT2A Q03164 2/20 0.41
KDM4E B2RXH2 1/20 0.41
PKM P14618 1/20 0.41
FAAH O00519 1/20 0.39
PHGDH O43175 1/20 0.39
MGLL Q99685 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39
EGFR P00533 1/20 0.39
ERBB2 P04626 1/20 0.39
HTT P42858 1/20 0.38
LMNA P02545 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
MAOA P21397 1/20 0.38
NPC1 O15118 1/20 0.38
ALDH1A1 P00352 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10724394 0.79 NPSR1 (0.41) POLBKMT2AHTTL3MBTL1NPC1
SCHEMBL307624 0.76 KMT2A (0.42) POLBKMT2AKDM4EPKMFAAH
SCHEMBL30937191 0.75 KMT2A (0.41) POLBKMT2AKDM4EPKMFAAH
SCHEMBL307698 0.74 OPRK1 (0.47) POLBKMT2AKDM4EPKMFAAH
SCHEMBL9001884 0.73 MEN1 (0.48) KMT2APKMMAOAALDH1A1
SCHEMBL13830993 0.73 KMT2A (0.42) POLBKMT2AKDM4EPKMFAAH
SCHEMBL3455674 0.72 HSD11B1 (0.49) KMT2AKDM4EHTTLMNAALDH1A1
SCHEMBL29184152 0.70 PKM (0.43) POLBKMT2AKDM4EPKMFAAH
SCHEMBL61173 0.70 POLB (0.55) POLBKMT2AKDM4EPKMFAAH
SCHEMBL320116 0.69 POLB (0.59) POLBKMT2AKDM4EPKMFAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0245066-A2 Method for plant growth regulation ELI LILLY AND COMPANY (US) 1987-11-11 EP disclosed
US-4704156-A TRIHALOCYCLOPROPANECARBOXYLIC ACID DERIVATIVES ELI LILLY AND COMPANY (US) 1987-11-03 US disclosed