Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL1072992 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3TDP1 | |
| Maleic Acid SCHEMBL10524567 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3TDP1 | |
| Fumaric Acid SCHEMBL27621050 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3TDP1 | |
| Maleic Acid SCHEMBL19458351 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3TDP1 | |
| Fumaric Acid SCHEMBL19458333 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3TDP1 | |
| Fumaric Acid SCHEMBL19458332 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3TDP1 | |
| Fumaric Acid SCHEMBL27661178 | 0.97 | TSHR (0.60) | TSHRTP53EGLN1EGLN3TDP1 | |
| SCHEMBL16431648 | 0.87 | — | — | |
| SCHEMBL27873511 | 0.87 | — | — | |
| SCHEMBL16431646 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025036900-A1 | HAIR DYEING COMPOSITION | KAO CORPORATION (JP) | 2025-02-20 | — | — | WO | claimed |
| CN-100372530-C | Tegaserod maleate oral preparation | JIANGSU AOSAIKANG PHARMACEUTIC (CN) | 2008-03-05 | — | — | CN | claimed |
| CN-1868461-A | Tegaserod maleate oral preparation | AOSAIKANG PHARMACEUTICAL CO LT (CN) | 2006-11-29 | — | — | CN | claimed |
| CN-1443535-A | Tegasevod maleate oral preparation and its preparation process-for curing intestinal irritability syndrome | NANCHANG HONGYI SCIENCE & TECH (CN) | 2003-09-24 | — | — | CN | claimed |
| US-12491493-B1 | Amine appended bimetallic metal-organic framework (MOF-74) for carbon dioxide capture and method of preparation thereof | KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) | 2025-12-09 | — | — | US | disclosed |
| WO-2025036900-A1 | HAIR DYEING COMPOSITION | KAO CORPORATION (JP) | 2025-02-20 | — | — | WO | disclosed |
| CN-114762685-A | Application of tegaserod maleate in treating acute myeloid leukemia and colorectal cancer | 陈璋辉 | 2022-07-19 | — | — | CN | disclosed |
| EP-1867672-B1 | EPOXY RESIN COMPOSITION | ASAHI KASEI CHEMICALS CORP (JP) | 2011-01-26 | — | — | EP | disclosed |
| US-20090032286-A1 | Epoxy Resin Composition | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2009-02-05 | — | — | US | disclosed |
| CN-100372530-C | Tegaserod maleate oral preparation | JIANGSU AOSAIKANG PHARMACEUTIC (CN) | 2008-03-05 | — | — | CN | disclosed |
| EP-1867672-A1 | EPOXY RESIN COMPOSITION | Asahi Kasei Chemicals Corporation (JP) | 2007-12-19 | — | — | EP | disclosed |
| CN-100333717-C | Oral solid preparation of water indissoluble medicine and/or acid sensitive medicinal composition | SHANGHAI INST PHARM INDUSTRY (CN) | 2007-08-29 | — | — | CN | disclosed |
| CN-1868461-A | Tegaserod maleate oral preparation | AOSAIKANG PHARMACEUTICAL CO LT (CN) | 2006-11-29 | — | — | CN | disclosed |
| CN-1621030-A | Oral solid preparation of water indissoluble medicine and/or acid sensitive medicinal composition | SHANGHAI INST PHARM INDUSTRY (CN) | 2005-06-01 | — | — | CN | disclosed |
| CN-1167415-C | Orally applied solid preparation of medicine difficult to dissolve | 中国人民解放军军事医学科学院毒物药 | 2004-09-22 | — | — | CN | disclosed |
| CN-1528293-A | Tegaserod maleate drop pill and preparing method thereof | 南昌弘益科技有限公司 | 2004-09-15 | — | — | CN | disclosed |
| CN-1443535-A | Tegasevod maleate oral preparation and its preparation process-for curing intestinal irritability syndrome | NANCHANG HONGYI SCIENCE & TECH (CN) | 2003-09-24 | — | — | CN | disclosed |
| CN-1305806-A | Orally applied solid preparation of medicine difficult to dissolve | INST OF TOXIC MEDICINE PLA ACA (CN) | 2001-08-01 | — | — | CN | disclosed |
| EP-0020173-A1 | Imidazole guanidines, their preparation and compositions containing them | MERCK & CO. INC. (US) | 1980-12-10 | — | — | EP | disclosed |