Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 6/20 | 0.46 |
| ▸ | STK17B | O94768 | 5/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351429 | 0.95 | SYK (0.47) | SYKSTK17ASTK17BHSP90AA1HSP90AB1 | |
| SCHEMBL8131156 | 0.89 | PRKCH (0.43) | SYKSTK17AFERMT2 | |
| Hydrochloric Acid SCHEMBL28301442 | 0.88 | PRKCH (0.43) | SYKSTK17AFERMT2 | |
| SCHEMBL10652657 | 0.79 | SYK (0.50) | SYKSTK17ASTK17BHSP90AA1HSP90AB1 | |
| SCHEMBL3846786 | 0.79 | KDM4E (0.47) | — | |
| SCHEMBL11389648 | 0.75 | ALDH1A1 (0.39) | — | |
| Hydrochloric Acid SCHEMBL6698771 | 0.74 | NPC1 (0.54) | SYKHSP90AA1HSP90AB1 | |
| SCHEMBL27879846 | 0.74 | RAB9A (0.46) | — | |
| SCHEMBL7367384 | 0.74 | ALDH1A1 (0.44) | — | |
| SCHEMBL8288918 | 0.73 | LMNA (0.64) | STK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112707-B1 | AMINOPYRIMIDINONE DERIVATIVES AS HISTAMINE H1-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-11-04 | — | — | EP | disclosed |
| US-4652650-A | Pyridylaminoalkylamine intermediates | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-03-24 | — | — | US | disclosed |
| US-4548940-A | Pyridylaminoalkylaminopyrimidones useful as histamine H1 -antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-10-22 | — | — | US | disclosed |
| EP-0112707-A2 | Aminopyrimidinone derivatives as histamine H1-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-07-04 | — | — | EP | disclosed |