SCHEMBL10731545

SCHEMBL10731545

C=CCc1cc(OC)c(OC)c([N+](=O)[O-])c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.55
GABRB2 P47870 1/20 0.55
ALDH1A1 P00352 6/20 0.52
HTT P42858 1/20 0.52
CYP3A4 P08684 4/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C9 P11712 1/20 0.51
HPGD P15428 1/20 0.51
CYP2C19 P33261 1/20 0.51
PPARG P37231 1/20 0.49
PPARD Q03181 1/20 0.49
PPARA Q07869 1/20 0.49
TUBB4A P04350 1/20 0.46
TUBB P07437 1/20 0.46
TUBA3C P0DPH7 1/20 0.46
TUBA1B P68363 1/20 0.46
TUBA4A P68366 1/20 0.46
TUBB4B P68371 1/20 0.46
TUBB3 Q13509 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10729189 0.85 GABRA1 (0.65) GABRA1GABRB2ALDH1A1HTTCYP3A4
SCHEMBL7075743 0.82 ALDH1A1 (0.63) GABRA1GABRB2ALDH1A1HTTCYP3A4
SCHEMBL68542 0.82 ALDH1A1 (0.63) GABRA1GABRB2ALDH1A1HTTCYP3A4
SCHEMBL13000171 0.81 TUBB4A (0.47) ALDH1A1HTTCYP3A4TUBB4ATUBB
SCHEMBL31005006 0.80 ALDH1A1 (0.61) GABRA1GABRB2ALDH1A1HTTCYP3A4
Fluoride SCHEMBL28006168 0.80 ALDH1A1 (0.61) GABRA1GABRB2ALDH1A1HTTCYP3A4
SCHEMBL13000195 0.80 TTR (0.53) ALDH1A1HTTTUBB4ATUBBTUBA3C
SCHEMBL17655660 0.77 TNKS (0.59) GABRA1GABRB2ALDH1A1HTTCYP3A4
SCHEMBL11553231 0.76 ALDH1A1 (0.53) ALDH1A1CYP3A4PPARGPPARDPPARA
SCHEMBL15514315 0.76 TUBB4A (0.60) ALDH1A1CYP3A4TUBB4ATUBBTUBA3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0101223-B1 PROCESS FOR PRODUCING PHENYLACETONES UBE INDUSTRIES, LTD. (JP) 1987-04-01 EP disclosed
US-4638094-A OXIDATION OF PROPYLENEBENZENES UBE INDUSTRIES, LTD. (JP) 1987-01-20 US disclosed
EP-0101223-A2 Process for producing phenylacetones UBE INDUSTRIES, LTD. (JP) 1984-02-22 EP disclosed