Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412394 | 0.99 | SRC (0.43) | SRCKDM4EPOLBHSD17B10L3MBTL1 | |
| Water SCHEMBL7408556 | 0.97 | SRC (0.42) | SRCKDM4EPOLBHSD17B10L3MBTL1 | |
| Ethylamine SCHEMBL7408665 | 0.94 | SRC (0.43) | SRCKDM4EPOLBHSD17B10L3MBTL1 | |
| SCHEMBL10968820 | 0.90 | FABP4 (0.43) | SRCKDM4EPOLBL3MBTL1DYRK1A | |
| SCHEMBL7407905 | 0.88 | KMO (0.39) | SRCKDM4EPOLBHSD17B10L3MBTL1 | |
| SCHEMBL7412064 | 0.86 | KDM4E (0.37) | SRCKDM4EPOLBHSD17B10L3MBTL1 | |
| Potassium Ion SCHEMBL7415696 | 0.85 | SRC (0.38) | SRCKDM4EPOLBHSD17B10L3MBTL1 | |
| Potassium Ion SCHEMBL7409882 | 0.85 | SRC (0.38) | SRCKDM4EPOLBHSD17B10L3MBTL1 | |
| Bromide SCHEMBL10739102 | 0.84 | SRC (0.43) | SRCKDM4EPOLBHSD17B10L3MBTL1 | |
| SCHEMBL10621799 | 0.83 | TNF (0.47) | SRCKDM4EPOLBL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4645836-A | Process for the preparation of 6,7-dihydroxy-4-alkyl-2(1H) quinazolinone-1-propionic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-02-24 | — | — | US | disclosed |