Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 4/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048553 | 0.89 | MAPT (0.58) | LMNAKMT2AUSP2MAPTDRD4 | |
| SCHEMBL10732710 | 0.85 | USP2 (0.60) | LMNAKMT2AUSP2MAPTDRD4 | |
| SCHEMBL10728158 | 0.84 | LMNA (0.62) | LMNAKMT2AUSP2MAPTDRD4 | |
| SCHEMBL8047488 | 0.81 | DRD2 (0.56) | LMNAKMT2AUSP2MAPTDRD4 | |
| SCHEMBL10728148 | 0.81 | DRD2 (0.60) | DRD4DRD2ADRA1ADRD3HTR1A | |
| SCHEMBL10733634 | 0.80 | MAPT (0.51) | LMNAKMT2AUSP2MAPTDRD4 | |
| SCHEMBL8054110 | 0.79 | DRD2 (0.59) | LMNAKMT2AUSP2MAPTDRD4 | |
| SCHEMBL8051079 | 0.78 | LMNA (0.55) | LMNAKMT2AUSP2MAPTDRD4 | |
| SCHEMBL10732716 | 0.76 | MAPT (0.52) | LMNAKMT2AUSP2MAPTDRD2 | |
| SCHEMBL10729287 | 0.74 | LMNA (0.66) | LMNAKMT2AUSP2MAPTDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4707550-A | N-(substituted thienyl)-N'-(substituted piperazinyl)-ureas | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-11-17 | — | — | US | claimed |
| US-4707550-A | N-(substituted thienyl)-N'-(substituted piperazinyl)-ureas | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-11-17 | — | — | US | disclosed |
| EP-0244176-A2 | Thienopyrimidine-2,4-dione derivatives and intermediates thereof | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-11-04 | — | — | EP | disclosed |
| US-4670560-A | VASODILATING AGENTS, HYPOTENSIVE AGENTS AND/OR CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-06-02 | — | — | US | disclosed |