Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.56 |
| ▸ | DRD4 | P21917 | 8/20 | 0.56 |
| ▸ | DRD3 | P35462 | 7/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.55 |
| ▸ | DRD1 | P21728 | 3/20 | 0.55 |
| ▸ | DRD5 | P21918 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10728158 | 0.90 | LMNA (0.62) | DRD2DRD4DRD3LMNAMAPT | |
| SCHEMBL8054110 | 0.85 | DRD2 (0.59) | DRD2DRD4DRD3LMNAMAPT | |
| SCHEMBL8048553 | 0.85 | MAPT (0.58) | DRD2DRD4DRD3LMNAMAPT | |
| SCHEMBL10732710 | 0.81 | USP2 (0.60) | DRD2DRD4DRD3LMNAMAPT | |
| SCHEMBL10733643 | 0.81 | LMNA (0.57) | DRD2DRD4DRD3LMNAMAPT | |
| SCHEMBL8051079 | 0.80 | LMNA (0.55) | DRD2DRD4DRD3LMNAMAPT | |
| SCHEMBL8051341 | 0.77 | ALDH1A1 (0.64) | LMNAMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL10728148 | 0.77 | DRD2 (0.60) | DRD2DRD4DRD3HTR1AADRA2A | |
| SCHEMBL13837687 | 0.74 | ALDH1A1 (0.73) | LMNAMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL9760311 | 0.73 | HTR1A (0.58) | DRD2DRD4HTR1AADRA2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166019-A | Piperazinyl pyrimidine dione compounds selective for adrenoceptors | ABBOTT LABORATORIES (US) | 2000-12-26 | — | — | US | disclosed |
| US-6153614-A | Piperazinyl pyrimidine dione compounds selective for adrenoceptors | ABBOTT LABORATORIES (US) | 2000-11-28 | — | — | US | disclosed |