Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 16/20 | 0.33 |
| ▸ | PDE4A | P27815 | 8/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10740250 | 0.81 | METAP2 (0.45) | METAP2METAP1PDE5APDE4APDE4B | |
| SCHEMBL10736815 | 0.81 | METAP2 (0.44) | METAP2METAP1PDE5APDE4APDE4B | |
| SCHEMBL10739070 | 0.78 | METAP2 (0.40) | METAP2METAP1AURKA | |
| SCHEMBL10736658 | 0.76 | METAP2 (0.39) | METAP2METAP1AURKA | |
| SCHEMBL9636132 | 0.76 | PDE5A (0.39) | METAP2METAP1PDE5A | |
| SCHEMBL10754042 | 0.74 | PDE2A (0.41) | METAP2METAP1PDE5APDE4APDE4B | |
| SCHEMBL10735983 | 0.73 | PDE5A (0.48) | METAP2METAP1PDE5APDE4APDE4B | |
| SCHEMBL10739221 | 0.73 | ALDH1A1 (0.33) | PDE5A | |
| SCHEMBL10734350 | 0.72 | PDE5A (0.50) | METAP2METAP1PDE5APDE4APDE4B | |
| SCHEMBL10733013 | 0.71 | MAOA (0.36) | METAP2METAP1PDE5APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4654344-A | ALSO AFFECT BLOOD PRESSURE AND MYOCARDIAL CONTRACTIONS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1987-03-31 | — | — | US | disclosed |
| EP-0093951-B1 | 2-ARYL-TETRAAZAINDENES | MERCK PATENT GmbH (DE) | 1986-10-29 | — | — | EP | disclosed |
| US-4575505-A | Pharmaceutical compositions containing 2-aryltetraazaindenes for treating ulcers or cardiac insufficiency or blood pressure abnormalities | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-03-11 | — | — | US | disclosed |
| US-4477454-A | INDOTROPIC AGENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-16 | — | — | US | disclosed |
| EP-0093951-A2 | 2-Aryl-tetraazaindenes | MERCK PATENT GmbH (DE) | 1983-11-16 | — | — | EP | disclosed |