Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD5 | P21918 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | THPO | P40225 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10738526 | 0.77 | MAPK1 (0.60) | PARP1CYP3A4DRD1DRD2DRD5 | |
| SCHEMBL2839704 | 0.72 | GID4 (0.34) | GID4 | |
| SCHEMBL10735329 | 0.71 | SLC6A2 (0.41) | PARP1CYP3A4MEN1CYP2D6KMT2A | |
| SCHEMBL8493961 | 0.65 | MEN1 (0.42) | PARP1CYP3A4MEN1CYP2D6KMT2A | |
| SCHEMBL10938307 | 0.64 | DRD1 (0.77) | CYP3A4DRD1DRD2DRD5MAPK1 | |
| Hydrochloric Acid SCHEMBL11710504 | 0.63 | DRD1 (0.75) | CYP3A4DRD1DRD2DRD5MAPK1 | |
| SCHEMBL2840441 | 0.62 | GID4 (0.36) | GID4 | |
| SCHEMBL1728504 | 0.60 | ALDH1A1 (0.45) | CYP3A4MEN1CYP2D6KMT2AHTR2A | |
| Phosphine SCHEMBL29171493 | 0.58 | HTR2A (0.39) | CYP3A4MEN1CYP2D6KMT2AHTR2A | |
| SCHEMBL3567992 | 0.58 | MEN1 (0.44) | CYP3A4MEN1KMT2AHTR2ANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4636510-A | 4-phenyl-tetrahydro-furano-pyridines and anti-depressant pharmaceutical compositions containing same | BOEHRINGER INGELHEIM KG (DE) | 1987-01-13 | — | — | US | disclosed |
| EP-0123998-A2 | 4-Phenyl-tetrahydro-furano-pyridines, process for their preparation and pharmaceutical compositions | BOEHRINGER INGELHEIM KG (DE) | 1984-11-07 | — | — | EP | disclosed |