Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 7/20 | 1.00 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ADH5 | P11766 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320420 | 0.84 | PDE3A (0.72) | PDE3BPDE3ACRBNTBXAS1 | |
| SCHEMBL16097172 | 0.73 | PDE3B (0.57) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL10341518 | 0.72 | PDE3B (0.55) | PDE3BPDE3A | |
| SCHEMBL7290528 | 0.71 | PDE3B (1.00) | PDE3BPDE3APDE2AADH5 | |
| SCHEMBL28274911 | 0.71 | PDE3B (0.60) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL11121491 | 0.71 | PDE3B (0.55) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL7273296 | 0.71 | PDE3B (0.60) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| Hydrochloric Acid SCHEMBL7347426 | 0.71 | PDE3B (0.54) | PDE3BPDE3A | |
| SCHEMBL23137976 | 0.70 | PDE3B (0.56) | PDE3BPDE3ACRBNTBXAS1PRMT5 | |
| SCHEMBL5041825 | 0.70 | MAPK8 (0.53) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4602019-A | Indeno[1,2-c]pyridazin-3-one derivatives useful as cardiotonic and antihypertensive agents | WARNER-LAMBERT COMPANY (US) | 1986-07-22 | — | — | US | claimed |
| EP-0124314-A2 | Substituted-3H-indeno(1,2-c)pyridazin-3-ones | WARNER-LAMBERT COMPANY (US) | 1984-11-07 | — | — | EP | claimed |
| US-4701453-A | Substituted indeno-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1987-10-20 | — | — | US | disclosed |
| US-4602019-A | Indeno[1,2-c]pyridazin-3-one derivatives useful as cardiotonic and antihypertensive agents | WARNER-LAMBERT COMPANY (US) | 1986-07-22 | — | — | US | disclosed |
| EP-0124314-A2 | Substituted-3H-indeno(1,2-c)pyridazin-3-ones | WARNER-LAMBERT COMPANY (US) | 1984-11-07 | — | — | EP | disclosed |