Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.55 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11032841 | 0.71 | PDE3B (0.51) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL28274911 | 0.71 | PDE3B (0.60) | PDE3BPDE3ACRBNTBXAS1LMNA | |
| SCHEMBL10738544 | 0.71 | PDE3B (1.00) | PDE3BPDE3ACRBNTBXAS1CYP11B1 | |
| SCHEMBL7273296 | 0.71 | PDE3B (0.60) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL16097172 | 0.71 | PDE3B (0.57) | PDE3BPDE3ACRBNTBXAS1LMNA | |
| SCHEMBL23137976 | 0.70 | PDE3B (0.56) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL27928423 | 0.68 | PDE3B (0.54) | PDE3BPDE3ACRBNTBXAS1LMNA | |
| SCHEMBL20777317 | 0.68 | CRBN (1.00) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL10463333 | 0.68 | PDE3B (1.00) | PDE3BPDE3ACRBNTBXAS1PDE4A | |
| SCHEMBL30800784 | 0.68 | CRBN (1.00) | PDE3BPDE3ACRBNTBXAS1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0124314-A2 | Substituted-3H-indeno(1,2-c)pyridazin-3-ones | WARNER-LAMBERT COMPANY (US) | 1984-11-07 | — | — | EP | disclosed |