Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 7/20 | 1.00 |
| ▸ | PDE2A | O00408 | 2/20 | 0.52 |
| ▸ | ADH5 | P11766 | 7/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10551346 | 0.83 | PDE3B (0.70) | PDE3BPDE3APDE2AADH5ROCK1 | |
| SCHEMBL10353678 | 0.80 | PDE3B (0.63) | PDE3BPDE3AROCK1TSHRMEN1 | |
| SCHEMBL10649130 | 0.79 | PDE3B (0.65) | PDE3BPDE3APDE2AADH5PDE1A | |
| SCHEMBL10645524 | 0.76 | PDE3B (0.61) | PDE3BPDE3APDE2AADH5ROCK1 | |
| SCHEMBL7280366 | 0.75 | PDE3B (1.00) | PDE3BPDE3APDE2AADH5TSHR | |
| SCHEMBL10149837 | 0.75 | ROCK1 (0.76) | PDE3BPDE3APDE2AROCK1TSHR | |
| SCHEMBL10592873 | 0.73 | PDE3B (0.57) | PDE3BPDE3APDE2AROCK1TSHR | |
| SCHEMBL11101040 | 0.73 | PDE3B (0.57) | PDE3BPDE3AADH5TSHRMEN1 | |
| SCHEMBL5280816 | 0.73 | PDE3B (0.57) | PDE3BPDE3AROCK1TSHRMEN1 | |
| SCHEMBL10480619 | 0.73 | ROCK1 (0.60) | PDE3BPDE3APDE2AADH5ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | claimed |
| US-4734415-A | CARDIOTONIC, HYPOTENSIVE | WARNER-LAMBERT COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0122419-A2 | Substituted 3-mercaptopyridazines, their 3-alkylthio derivatives and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-10-24 | — | — | EP | disclosed |
| EP-0075436-A1 | Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted)phenyl-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1983-03-30 | — | — | EP | disclosed |