Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1071221 | 0.97 | ALDH1A1 (0.36) | ALDH1A1CYP1A2KDM4EALOX15TSHR | |
| Hydrochloric Acid SCHEMBL28930333 | 0.74 | ALDH1A1 (0.58) | ALDH1A1CYP1A2KDM4EALOX15TSHR | |
| Hydrochloric Acid SCHEMBL1071433 | 0.74 | ALDH1A1 (0.35) | ALDH1A1CYP1A2KDM4EALOX15TSHR | |
| SCHEMBL30924435 | 0.73 | — | — | |
| SCHEMBL30924436 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL1071457 | 0.71 | ALDH1A1 (0.35) | ALDH1A1CYP1A2KDM4EALOX15TSHR | |
| SCHEMBL455687 | 0.71 | KDM4E (0.59) | ALDH1A1CYP1A2KDM4EALOX15TSHR | |
| SCHEMBL5176456 | 0.69 | CYP1A2 (0.33) | ALDH1A1CYP1A2KDM4EALOX15TSHR | |
| SCHEMBL3875700 | 0.69 | CYP1A2 (0.33) | ALDH1A1CYP1A2KDM4EALOX15TSHR | |
| Hydrochloric Acid SCHEMBL27613793 | 0.69 | KDM4E (0.56) | ALDH1A1CYP1A2KDM4EALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824888-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2017-01-18 | — | — | EP | disclosed |
| EP-1740626-B1 | CATALYST SYSTEM FOR OLEFIN POLYMERIZATION, ITS PRODUCTION AND USE | BASELL POLYOLEFINE GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |
| EP-2459600-B1 | ORGANOMETALLIC TRANSITION METAL COMPOUND, CATALYST SYSTEM AND PREPARATION OF POLYOLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2013-11-20 | — | — | EP | disclosed |
| US-8471050-B2 | Organometallic transition metal compound, catalyst system and preparation of polyolefins | BASELL POLYOLEFINE GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| US-20120142874-A1 | Organometallic Transition Metal Compound, Catalyst System and Preparation of Polyolefins | BASELL POLYOLEFINE GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
| EP-2459600-A1 | ORGANOMETALLIC TRANSITION METAL COMPOUND, CATALYST SYSTEM AND PREPARATION OF POLYOLEFINS | Basell Polyolefine GmbH (DE) | 2012-06-06 | — | — | EP | disclosed |
| US-7973114-B2 | Monocyclopentadienyl complexes | BASELL POLYOLEFINE GMBH (DE) | 2011-07-05 | — | — | US | disclosed |
| WO-2011012245-A1 | ORGANOMETALLIC TRANSITION METAL COMPOUND, CATALYST SYSTEM AND PREPARATION OF POLYOLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2011-02-03 | — | — | WO | disclosed |
| EP-1861409-B1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2011-01-19 | — | — | EP | disclosed |
| US-7834112-B2 | Method of polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2010-11-16 | — | — | US | disclosed |
| WO-2004104052-A1 | TRANSITION-METAL COMPLEXES WITH TRIDENTATE, NITROGEN-CONTAINING LIGANDS | BASELL POLYOLEFINE GMBH (DE) | 2004-12-02 | — | — | WO | disclosed |
| US-6787499-B2 | Catalyst for the production of α-olefin and α-olefin production method | IDEMITSU PETROCHEMICAL CO., LTD. (JP) | 2004-09-07 | — | — | US | disclosed |
| WO-2004056481-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2004-07-08 | — | — | WO | disclosed |
| WO-2004056482-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2004-07-08 | — | — | WO | disclosed |
| WO-2004020479-A2 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2004-03-11 | — | — | WO | disclosed |
| WO-2004018489-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2004-03-04 | — | — | WO | disclosed |
| US-20030134991-A1 | Catalyst for the production of alpha-olefin and alpha-olefin production method thereof | IDEMITSU PETROCHEMICAL CO., LTD. (JP) | 2003-07-17 | — | — | US | disclosed |
| US-6555633-B1 | A alpha-olefin oligomerization catalyst obtained by contacting (a) a clay, clay mineral or ion-exchange layer compound with (b-1) a transition metal complex of group 4 to 6 of periodic table, and (a) is treated with organosilane compound | IDEMITSU PETROCHEMICAL CO., LTD. (JP) | 2003-04-29 | — | — | US | disclosed |
| EP-1106249-A1 | CATALYST FOR $g(a)-OLEFIN PRODUCTION AND PROCESS FOR PRODUCING $g(a)-OLEFIN | IDEMITSU PETROCHEMICAL CO., LTD. (JP) | 2001-06-13 | — | — | EP | disclosed |
| EP-1066877-A1 | CATALYSTS FOR $g(a)-OLEFIN PRODUCTION AND PROCESSES FOR PRODUCING $g(a)-OLEFIN | IDEMITSU PETROCHEMICAL CO., LTD. (JP) | 2001-01-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142874-A1 | Organometallic Transition Metal Compound, Catalyst System and Preparation of Polyolefins | PRMT9, INTS9, ACAD9 | ALDH1A1 2207/4885CYP1A2 956/4885KDM4E 2206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.