Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Homatropine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.67 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.54 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.54 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.95 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.95 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.92 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.92 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.92 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.92 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.92 |
| ▸ | BLM | P54132 | 2/20 | 0.92 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.92 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.92 |
| ▸ | HTR2C | P28335 | 3/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.67 |
| ▸ | HRH1 | P35367 | 2/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Homatropine SCHEMBL23468168 | 0.97 | LMNA (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL15275620 | 0.97 | LMNA (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL23969 | 0.97 | LMNA (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL9653008 | 0.97 | LMNA (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL23970 | 0.97 | LMNA (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL41951 | 0.96 | CHRM2 (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL41950 | 0.96 | CHRM2 (1.00) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL220965 | 0.96 | LMNA (0.97) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL220964 | 0.96 | LMNA (0.97) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| Homatropine SCHEMBL14672464 | 0.95 | LMNA (0.95) | LMNACYP2D6CYP2C9HSD17B10CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10351497-B2 | Use of a Lewis donor solvent to purify a feedstock that contains ethanol, acetaldehyde, and impurities | IFP Energies Nouvelles (FR) | 2019-07-16 | — | — | US | disclosed |
| US-20190144366-A1 | USE OF A LEWIS DONOR SOLVENT TO PURIFY A FEEDSTOCK THAT CONTAINS ETHANOL, ACETALDEHYDE, AND IMPURITIES | IFP Energies Nouvelles (JP) | 2019-05-16 | — | — | US | disclosed |
| US-10081588-B2 | Production of butyl acetate from ethanol | RESCURVE, LLC (US) | 2018-09-25 | — | — | US | disclosed |
| CN-105073697-B | Production of higher alcohols | 雷斯库尔有限责任公司 | 2017-05-24 | — | — | CN | disclosed |
| US-20160297737-A1 | Production of Butyl Acetate from Ethanol | VIRIDIS CHEMICAL, LLC | 2016-10-13 | — | — | US | disclosed |
| US-9018427-B2 | Production of higher alcohols | GREENYUG, LLC (US) | 2015-04-28 | — | — | US | disclosed |
| US-20140235901-A1 | Production of Higher Alcohols | GREENYUG, LLC (US) | 2014-08-21 | — | — | US | disclosed |
| US-4656294-A | MATRIX RESINS, SEALS | MITSUBISHI PETROCHEMICAL CO., LTD. (JP) | 1987-04-07 | — | — | US | disclosed |
| US-4456742-A | PROTECTIVE COATING | FMC CORPORATION (US) | 1984-06-26 | — | — | US | disclosed |
| US-4093677-A | POLYAMIDE-AMINE BLOCK POLYMERS | FERRUTI PAOLO | 1978-06-06 | — | — | US | disclosed |