Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10748283 | 0.85 | METAP2 (0.36) | METAP2ALDH1A1KDM4ENPSR1MAPT | |
| SCHEMBL10749509 | 0.85 | METAP2 (0.51) | METAP2ALDH1A1KDM4ENPSR1MAPT | |
| SCHEMBL10747393 | 0.85 | METAP2 (0.39) | METAP2ALDH1A1KDM4ENPSR1MAPT | |
| SCHEMBL10746433 | 0.80 | KMT2A (0.38) | ALDH1A1MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL10747007 | 0.75 | METAP2 (0.38) | METAP2ALDH1A1KDM4ENPSR1MAPT | |
| SCHEMBL10746662 | 0.72 | METAP2 (0.38) | METAP2ALDH1A1KDM4ENPSR1MAPT | |
| SCHEMBL10501643 | 0.71 | METAP2 (0.46) | METAP2ALDH1A1KDM4ENPSR1MAPT | |
| SCHEMBL10501842 | 0.71 | METAP2 (0.49) | METAP2ALDH1A1KDM4ENPSR1MAPT | |
| SCHEMBL10501413 | 0.70 | MPI (0.51) | METAP2ALDH1A1LMNAUSP2 | |
| SCHEMBL10501411 | 0.70 | METAP2 (0.38) | METAP2ALDH1A1KDM4ENPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |