Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 6/20 | 0.52 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.43 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.43 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | MMP10 | P09238 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916746 | 0.89 | METAP2 (0.53) | METAP2TXNRD1TXNRD3TXNRD2KDM4E | |
| SCHEMBL10745708 | 0.89 | TXNRD1 (0.56) | METAP2TXNRD1TXNRD3TXNRD2BACE1 | |
| SCHEMBL10748075 | 0.83 | MAPT (0.40) | METAP2KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL10747513 | 0.81 | MPI (0.50) | METAP2KDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL5916699 | 0.80 | METAP2 (0.46) | METAP2TXNRD1TXNRD3TXNRD2KDM4E | |
| SCHEMBL10501793 | 0.80 | TXNRD1 (0.52) | METAP2TXNRD1TXNRD3TXNRD2KDM4E | |
| SCHEMBL10501293 | 0.80 | METAP2 (0.69) | METAP2TXNRD1TXNRD3TXNRD2KDM4E | |
| SCHEMBL10745150 | 0.78 | METAP2 (0.45) | METAP2 | |
| SCHEMBL10745465 | 0.78 | METAP2 (0.48) | METAP2KDM4EALDH1A1BACE1KMT2A | |
| SCHEMBL5916782 | 0.76 | METAP2 (0.61) | METAP2KDM4EALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |