Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.56 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.56 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.56 |
| ▸ | METAP2 | P50579 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | MMP10 | P09238 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10746470 | 0.89 | METAP2 (0.52) | TXNRD1TXNRD3TXNRD2METAP2MAPT | |
| SCHEMBL10501793 | 0.88 | TXNRD1 (0.52) | TXNRD1TXNRD3TXNRD2METAP2KAT2B | |
| SCHEMBL10746448 | 0.83 | TXNRD1 (0.43) | TXNRD1TXNRD3TXNRD2METAP2NPC1 | |
| SCHEMBL10501657 | 0.81 | METAP2 (0.71) | TXNRD1TXNRD3TXNRD2METAP2MAPT | |
| SCHEMBL10502494 | 0.80 | TXNRD1 (0.52) | TXNRD1TXNRD3TXNRD2METAP2NPC1 | |
| SCHEMBL5916746 | 0.78 | METAP2 (0.53) | TXNRD1TXNRD3TXNRD2METAP2 | |
| SCHEMBL10745932 | 0.78 | METAP2 (0.45) | METAP2MAPTKMT2A | |
| SCHEMBL11020733 | 0.77 | METAP2 (0.38) | TXNRD1TXNRD3TXNRD2METAP2NPC1 | |
| SCHEMBL5916782 | 0.76 | METAP2 (0.61) | METAP2MAPTKMT2A | |
| SCHEMBL10748075 | 0.75 | MAPT (0.40) | METAP2NPC1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |