Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916590 | 0.83 | METAP2 (0.55) | KDM4ELMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10748399 | 0.76 | CYP3A4 (0.39) | KDM4ELMNACYP3A4ALDH1A1MAPT | |
| SCHEMBL10748809 | 0.76 | CYP3A4 (0.46) | KDM4ELMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10502470 | 0.74 | METAP2 (0.46) | KDM4ELMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10746610 | 0.74 | MAPK1 (0.43) | KDM4ECYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL10502592 | 0.74 | ALDH1A1 (0.42) | KDM4ELMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10746688 | 0.72 | KDM4E (0.35) | KDM4ELMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10501640 | 0.71 | METAP2 (0.37) | KDM4ELMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10502616 | 0.71 | METAP2 (0.46) | KDM4ELMNACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10502354 | 0.71 | METAP2 (0.41) | KDM4ELMNACYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |