Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | IDH2 | P48735 | 2/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057840 | 0.85 | LMNA (0.50) | SMN1; SMN2LMNAMAPTKMT2AMEN1 | |
| SCHEMBL8432702 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAMAPTCYP1A2CYP2C19 | |
| SCHEMBL5966376 | 0.82 | NPSR1 (0.49) | SMN1; SMN2LMNAMAPTCYP1A2CYP2C19 | |
| SCHEMBL9526292 | 0.81 | TSHR (0.40) | SMN1; SMN2LMNAMAPTCYP1A2CYP2C19 | |
| SCHEMBL11269602 | 0.81 | GAA (0.38) | SMN1; SMN2LMNAMAPTCYP1A2CYP2C19 | |
| SCHEMBL8464395 | 0.81 | KMT2A (0.46) | SMN1; SMN2LMNAMAPTCYP1A2CYP2C19 | |
| SCHEMBL10619199 | 0.80 | SMN1; SMN2 (0.74) | SMN1; SMN2LMNAMAPTCYP1A2CYP2C19 | |
| SCHEMBL5966347 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAMAPTCYP1A2CYP2C19 | |
| SCHEMBL11269609 | 0.78 | KCNH3 (0.45) | SMN1; SMN2LMNAMAPTCYP1A2CYP2C19 | |
| SCHEMBL11788223 | 0.73 | PDE4A (0.37) | SMN1; SMN2LMNAPDE4AKMT2ACDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240854-A1 | Bis-tert-butylamino-substituted 1,3,5-triazine derivatives, process for their preparation, medicaments containing these compounds, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-10-14 | — | — | EP | disclosed |