Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10745020 | 0.79 | KDM4E (0.48) | KDM4ELMNAMAPTDRD4DRD2 | |
| SCHEMBL10741002 | 0.77 | DRD2 (0.58) | KDM4ELMNAMAPTDRD4DRD2 | |
| SCHEMBL10748537 | 0.73 | MCHR1 (0.38) | MCHR1 | |
| SCHEMBL10742755 | 0.72 | DRD2 (0.49) | KDM4ELMNAMAPTDRD4DRD2 | |
| SCHEMBL10745251 | 0.71 | DRD2 (0.48) | KDM4ELMNAMAPTDRD4DRD2 | |
| SCHEMBL13064448 | 0.71 | MCHR1 (0.43) | DRD2MCHR1 | |
| SCHEMBL10749274 | 0.71 | DRD2 (0.48) | KDM4ELMNAMAPTDRD4DRD2 | |
| SCHEMBL10742344 | 0.71 | DRD2 (0.53) | KDM4ELMNAMAPTDRD4DRD2 | |
| SCHEMBL10748978 | 0.70 | DRD2 (0.52) | KDM4ELMNAMAPTDRD4DRD2 | |
| SCHEMBL10747134 | 0.69 | DRD2 (0.50) | KDM4EMAPTDRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4698351-A | Tetrahydrocarbazole derivatives and pharmaceutical compositions | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1987-10-06 | — | — | US | disclosed |
| US-4618614-A | Method of treating psychosis using tetrahydrocarbazole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-21 | — | — | US | disclosed |
| US-4547576-A | Tetrahydrocarbazole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-10-15 | — | — | US | disclosed |