Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18998180 | 0.87 | GABRA1 (0.54) | KDM4EALDH1A1L3MBTL1GABRA1GABRG2 | |
| SCHEMBL1074997 | 0.87 | MAT2A (0.45) | KDM4EALDH1A1POLBL3MBTL1GABRA1 | |
| SCHEMBL31439285 | 0.84 | MTOR (0.50) | KDM4EALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL16719262 | 0.84 | MTOR (0.50) | KDM4EALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL5653378 | 0.81 | PIK3CA (0.42) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL17272559 | 0.80 | AURKA (0.42) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL20390762 | 0.80 | PIK3CA (0.44) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL31439289 | 0.80 | PIK3CA (0.47) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL31439381 | 0.80 | PIK3CA (0.44) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL31439349 | 0.79 | GABRA1 (0.38) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448937-A1 | IMIDAZO [4,5-C]QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF TUMORS AND/OR INFLAMMATION | Piramal Life Sciences Limited (IN) | 2012-05-09 | — | — | EP | disclosed |
| US-20120108627-A1 | IMIDAZO [4,5-C]QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF TUMORS AND/OR INFLAMMATION | Piramal Enterprises Limited (IN) | 2012-05-03 | — | — | US | disclosed |
| WO-2011001212-A1 | IMIDAZO [4,5-C]QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF TUMORS AND/OR INFLAMMATION | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108627-A1 | IMIDAZO [4,5-C]QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF TUMORS AND/OR INFLAMMATION | IL6, RPS6KA6, MTOR | KDM4E 2337/4885ALDH1A1 3946/4885POLB 2510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.