SCHEMBL10749219

SCHEMBL10749219

C=CCC(S)(CC=C)CC(=O)O

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.35
TSHR P16473 2/20 0.35
HMGCR P04035 1/20 0.33
CHRM1 P11229 1/20 0.33
TBXA2R P21731 1/20 0.33
ADRA1A P35348 1/20 0.33
HTT P42858 1/20 0.33
ABCC4 O15439 1/20 0.32
MAPT P10636 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
HIF1A Q16665 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28638233 0.81 ALDH1A1 (0.35) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL11583210 0.77 ALDH1A1 (0.37) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL13347361 0.75 ALDH1A1 (0.38) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL5505469 0.73 ALDH1A1 (0.40) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL3774113 0.73 ALDH1A1 (0.40) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL29618244 0.73 ACLY (0.34) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL3851443 0.73
SCHEMBL1680225 0.71 ALDH1A1 (0.39) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL16438125 0.71 HMGCR (0.64) ALDH1A1TSHRHMGCRCHRM1TBXA2R
SCHEMBL10695777 0.71 ACLY (0.37) ALDH1A1TSHRHMGCRCHRM1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4684622-A CYCLIC OLIGOPEPTIDES, DISULFIDE LINKAGE SMITHKLINE BECKMAN CORPORATION (US) 1987-08-04 US disclosed
US-4599324-A VASODILATORS SMITHKLINE BECKMAN CORPORATION (US) 1986-07-08 US disclosed
EP-0182626-A2 V1-vasopressin antagonists SMITHKLINE BECKMAN CORPORATION (US) 1986-05-28 EP disclosed