Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HMGCR | P04035 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5505469 | 0.95 | ALDH1A1 (0.40) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL8771120 | 0.79 | HSPD1 (0.37) | ALDH1A1TSHRCPT2 | |
| SCHEMBL16438125 | 0.78 | HMGCR (0.64) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL1680225 | 0.78 | ALDH1A1 (0.39) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL10974694 | 0.78 | HMGCR (0.64) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1071338 | 0.78 | ALDH1A1 (0.56) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL13347361 | 0.77 | ALDH1A1 (0.38) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL909920 | 0.76 | ALDH1A1 (0.61) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL6048123 | 0.74 | TSHR (0.38) | ALDH1A1TSHRMAPT | |
| SCHEMBL880688 | 0.74 | ALDH1A1 (0.56) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120121554-A1 | HMG-COA SECONDARY METABOLITES AND USES THEREOF | EDENSPACE SYSTEMS CORPORATION (US) | 2012-05-17 | — | — | US | disclosed |
| WO-2010127313-A1 | HMG-COA SECONDARY METABOLITES AND USES THEREOF | EDENSPACE SYSTEMS CORPORATION (US) | 2010-11-04 | — | — | WO | disclosed |
| US-5236946-A | Hypercholesterolemia; regulates cholesterol production by inhibiting HMG-COA reductase | PANMEDICA S.A. (FR) | 1993-08-17 | — | — | US | disclosed |
| US-5134157-A | Trimethylcyclohexyl Pyroglutamate, Antilipemic Agents | PANMEDICA S.A. (FR) | 1992-07-28 | — | — | US | disclosed |
| EP-0089674-B1 | PENTANEDIOIC ACID DERIVATIVES | G.D. Searle & Co. (US) | 1985-12-27 | — | — | EP | disclosed |
| EP-0089674-A1 | Pentanedioic acid derivatives | G.D. Searle & Co. (US) | 1983-09-28 | — | — | EP | disclosed |
| US-4404144-A | Unsaturated analogs of β-alkyl-β-hydroxy glutaric acid and esters thereof | G. D. SEARLE & CO. (US) | 1983-09-13 | — | — | US | disclosed |