Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 4/20 | 0.42 |
| ▸ | ACE | P12821 | 2/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | ECE1 | P42892 | 3/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10750427 | 0.88 | HRH4 (0.45) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL10748375 | 0.88 | REN (0.43) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL8481892 | 0.85 | HRH4 (0.56) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL8481399 | 0.85 | HRH4 (0.56) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL8481408 | 0.85 | HRH4 (0.56) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL10748105 | 0.84 | REN (0.43) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL10570975 | 0.84 | HRH4 (0.47) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL10570967 | 0.84 | HRH4 (0.47) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL10749770 | 0.84 | REN (0.44) | HRH4MMEACECPA1ACE2 | |
| SCHEMBL10521239 | 0.83 | HRH4 (0.48) | HRH4MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4656269-A | RENIN INHIBITORY EFFECT WHEN ADMINISTERING ORALLY; HYPOTENSIVE AGENTS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1987-04-07 | — | — | US | disclosed |