Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10748364 | 0.79 | SMN1; SMN2 (0.40) | SMN1; SMN2L3MBTL1GAAHTR1AHTR1D | |
| SCHEMBL10750236 | 0.77 | SMN1; SMN2 (0.37) | SMN1; SMN2L3MBTL1GAAHTR1AHTR1D | |
| SCHEMBL10749350 | 0.73 | HTR1A (0.35) | SMN1; SMN2L3MBTL1GAAHTR1AHTR1D | |
| SCHEMBL378169 | 0.73 | SMN1; SMN2 (0.62) | SMN1; SMN2L3MBTL1GAANPC1RAB9A | |
| SCHEMBL10750240 | 0.72 | ADAM17 (0.48) | SMN1; SMN2L3MBTL1HTR1AHTR1DNPC1 | |
| SCHEMBL23657165 | 0.71 | CYP1A2 (0.58) | SMN1; SMN2L3MBTL1NPC1RAB9ALMNA | |
| SCHEMBL10748367 | 0.71 | SMN1; SMN2 (0.46) | SMN1; SMN2L3MBTL1GAANPC1RAB9A | |
| SCHEMBL5683250 | 0.71 | — | — | |
| SCHEMBL10752626 | 0.70 | NPC1 (0.35) | SMN1; SMN2L3MBTL1GAANPC1RAB9A | |
| SCHEMBL10753343 | 0.70 | NPC1 (0.36) | SMN1; SMN2L3MBTL1GAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4634704-A | HISTAMINE AND SEROTONINE ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-01-06 | — | — | US | disclosed |