Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933546 | 0.90 | KMT2A (0.52) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL14288602 | 0.86 | KMT2A (0.53) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL10783415 | 0.85 | LMNA (0.48) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL16054397 | 0.84 | KDM4E (0.62) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL10753830 | 0.81 | LMNA (0.47) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL171686 | 0.80 | KMT2A (0.63) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL10748434 | 0.80 | KMT2A (0.51) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL10781647 | 0.78 | L3MBTL1 (0.43) | LMNANPC1KDM4EMAPTKMT2A | |
| SCHEMBL10754632 | 0.77 | LMNA (0.51) | SMN1; SMN2RAB9ALMNANPC1TP53 | |
| SCHEMBL10750366 | 0.76 | NPC1 (0.54) | SMN1; SMN2RAB9ALMNANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4659737-A | Substituted aminomethyl benzopyrans having anti-hypertensive activities | BAYER AKTIENGESELLSCHAFT (DE) | 1987-04-21 | — | — | US | disclosed |
| US-4647579-A | Circulation active novel substituted 4-hydroxy-benzopyrans | BAYER AKTIENGESELLSCHAFT (DE) | 1987-03-03 | — | — | US | disclosed |