Sugi Predict

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SCHEMBL1075431

SCHEMBL1075431

CC(C)(C)OC(=O)N1CCC(c2nc(C(F)(F)F)ccc2N)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IDH1 O75874 1/20 0.46
▸ IDH2 P48735 1/20 0.46
▸ KDM4E B2RXH2 2/20 0.45
▸ MAPT P10636 1/20 0.45
▸ THRB P10828 1/20 0.45
▸ GPR119 Q8TDV5 7/20 0.44
▸ JAK2 O60674 1/20 0.44
▸ JAK1 P23458 1/20 0.44
▸ TYK2 P29597 1/20 0.44
▸ JAK3 P52333 1/20 0.44
▸ STS P08842 2/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ HPGD P15428 1/20 0.43
▸ TSHR P16473 1/20 0.43
▸ CRHBP P24387 1/20 0.43
▸ HTT P42858 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ CRHR2 Q13324 1/20 0.43
▸ HSD17B10 Q99714 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26602491 0.85 MEN1 (0.47) KDM4EMAPTTHRBGPR119JAK2
SCHEMBL30625181 0.85 MEN1 (0.47) KDM4EMAPTTHRBGPR119JAK2
SCHEMBL1727311 0.84 KDM4E (0.46) KDM4EMAPTTHRBGPR119JAK2
SCHEMBL1463986 0.82 KDM4E (0.46) KDM4EMAPTTHRBGPR119STS
SCHEMBL1421120 0.82 KDM4E (0.46) KDM4EMAPTTHRBGPR119STS
SCHEMBL1463324 0.81 KDM4E (0.45) IDH1IDH2KDM4EMAPTTHRB
SCHEMBL1725956 0.81 KDM4E (0.44) KDM4EMAPTTHRBGPR119JAK2
SCHEMBL1463180 0.79 KDM4E (0.45) KDM4EMAPTTHRBGPR119STS
SCHEMBL1421111 0.79 KDM4E (0.47) KDM4EMAPTTHRBGPR119STS
SCHEMBL26066077 0.78 TGM2 (0.49) IDH1IDH2GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10034476-B2 Insecticidal phenyl-or pyridyl-piperdine compounds SYNGENTA PARTICIPATIONS AG (CH) 2018-07-31 — — US disclosed
US-20170347650-A1 INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2017-12-07 — — US disclosed
US-9808006-B2 Insecticidal phenyl-or pyridyl-piperdine compounds SYNGENTA PARTICIPATIONS AG (CH) 2017-11-07 — — US disclosed
EP-2451801-B1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2014-08-13 — — EP disclosed
US-20130317062-A1 INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2013-11-28 — — US disclosed
US-8586593-B2 Insecticidal compounds SYNGENTA CROP PROTECTION, INC. (US) 2013-11-19 — — US disclosed
US-8518971-B2 Insecticidal phenyl- or pyridyl-piperdine compounds SYNGENTA CROP PROTECTION, INC. (US) 2013-08-27 — — US disclosed
US-8193362-B2 Insecticidal compounds SYNGENTA CROP PROTECTION LLC (US) 2012-06-05 — — US disclosed
EP-2451801-A1 INSECTICIDAL COMPOUNDS Syngenta Participations AG (CH) 2012-05-16 — — EP disclosed
WO-2012037282-A3 CATALYSTS AND METHODS FOR POLYMER SYNTHESIS NOVOMER, INC. (US) 2012-05-10 — — WO disclosed
US-20120115884-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION LLC (US) 2012-05-10 — — US disclosed
EP-2297136-B1 INSECTICIDAL PYRIDYLPIPERIDINE COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2011-12-28 — — EP disclosed
EP-2324010-B1 INSECTICIDAL PHENYL- OR PYRIDYL-PIPERIDINE COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2011-11-30 — — EP disclosed
US-20110136866-A1 INSECTICIDAL PHENYL- OR PYRIDYL-PIPERDINE COMPOUNDS SYNGENTA CROP PROTECTION LLC (US) 2011-06-09 — — US disclosed
EP-2324010-A1 INSECTICIDAL PHENYL- OR PYRIDYL-PIPERIDINE COMPOUNDS Syngenta Participations AG (CH) 2011-05-25 — — EP disclosed
US-20110071191-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, INC. (US) 2011-03-24 — — US disclosed
EP-2297136-A2 INSECTICIDAL PYRIDYLPIPERIDINE COMPOUNDS Syngenta Participations AG (CH) 2011-03-23 — — EP disclosed
WO-2011003684-A1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2011-01-13 — — WO disclosed
WO-2010009968-A1 INSECTICIDAL PHENYL- OR PYRIDYL-PIPERIDINE COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2010-01-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10034476-B2 Insecticidal phenyl-or pyridyl-piperdine compounds ACHE, CHRM1, CHRM2 IDH1 2735/4885IDH2 2451/4885KDM4E 1032/4885
US-20120115884-A1 INSECTICIDAL COMPOUNDS ACHE, C1R, C5 IDH1 2610/4885IDH2 2218/4885KDM4E 1708/4885
US-20130317062-A1 INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS ACHE, CHRM1, CHRM2 IDH1 2735/4885IDH2 2451/4885KDM4E 1032/4885
US-20110071191-A1 INSECTICIDAL COMPOUNDS CBR3, CBR1, ACHE IDH1 1187/4885IDH2 1592/4885KDM4E 1894/4885
US-20110136866-A1 INSECTICIDAL PHENYL- OR PYRIDYL-PIPERDINE COMPOUNDS ACHE, CHRM1, CHRM2 IDH1 2964/4885IDH2 2685/4885KDM4E 1079/4885
US-20170347650-A1 INSECTICIDAL PHENYL-OR PYRIDYL-PIPERDINE COMPOUNDS ACHE, CHRM1, CHRM2 IDH1 2735/4885IDH2 2451/4885KDM4E 1032/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.