Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10852417 | 1.00 | ATM (0.41) | ATMBRD4DRD2HTR1ASMN1; SMN2 | |
| SCHEMBL10921784 | 0.86 | GAA (0.39) | BRD4MTNR1AMTNR1BMAPTGAA | |
| SCHEMBL10754195 | 0.77 | ACHE (0.38) | ATMBRD4DRD2HTR1AACHE | |
| SCHEMBL10756153 | 0.77 | ATM (0.41) | ATMBRD4DRD2HTR1ASMN1; SMN2 | |
| SCHEMBL10761527 | 0.77 | BRD4 (0.41) | BRD4DRD2HTR1AACHETSHR | |
| SCHEMBL10761523 | 0.77 | BRD4 (0.41) | BRD4DRD2HTR1AACHETSHR | |
| SCHEMBL10754177 | 0.77 | ATM (0.39) | ATMBRD4DRD2HTR1ASMN1; SMN2 | |
| SCHEMBL10762532 | 0.73 | ATM (0.39) | ATMBRD4DRD2SMN1; SMN2MEN1 | |
| SCHEMBL10762535 | 0.73 | ATM (0.39) | ATMBRD4DRD2SMN1; SMN2MEN1 | |
| SCHEMBL8568355 | 0.72 | MTNR1A (0.50) | ATMBRD4DRD2SMN1; SMN2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4585588-A | ANTIDEPRESSANTS | BEECHAM GROUP P.L.C. (GB) | 1986-04-29 | — | — | US | claimed |
| US-4638066-A | ANTIDEPRESSANTS | BEECHAM GROUP P.L.C. (GB) | 1987-01-20 | — | — | US | disclosed |
| EP-0088575-B1 | PENTACYCLIC COMPOUNDS | BEECHAM GROUP PLC (GB) | 1986-12-30 | — | — | EP | disclosed |
| US-4585588-A | ANTIDEPRESSANTS | BEECHAM GROUP P.L.C. (GB) | 1986-04-29 | — | — | US | disclosed |
| US-4504480-A | DIAZABENZOCYCLOHEPTAFLUORENE DERIVATRIVES, ANTIDEPRESSANTS | BEECHAM GROUP P.L.C. (GB) | 1985-03-12 | — | — | US | disclosed |
| EP-0088575-A2 | Pentacyclic compounds | BEECHAM GROUP PLC (GB) | 1983-09-14 | — | — | EP | disclosed |