SCHEMBL10756337

SCHEMBL10756337

CCOC(=O)c1nc(-c2ccccc2)nc2ccccc12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.61
CYP1A2 P05177 4/20 0.61
CYP2C9 P11712 4/20 0.61
CYP2C19 P33261 4/20 0.61
PRNP P04156 2/20 0.61
L3MBTL1 Q9Y468 2/20 0.61
POLB P06746 1/20 0.61
RXFP1 Q9HBX9 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
SMN1; SMN2 Q16637 4/20 0.58
LMNA P02545 4/20 0.58
MEN1 O00255 1/20 0.58
KMT2A Q03164 1/20 0.58
PDE5A O76074 1/20 0.56
KDM4E B2RXH2 4/20 0.56
RAB9A P51151 2/20 0.56
TP53 P04637 1/20 0.56
HSD17B10 Q99714 1/20 0.56
TSPO P30536 2/20 0.53
TACR3 P29371 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16038710 0.93 MAPT (0.54) MAPTCYP1A2CYP2C9CYP2C19PRNP
SCHEMBL16038902 0.91 KDM4E (0.53) MAPTCYP1A2CYP2C9CYP2C19PRNP
SCHEMBL16037705 0.91 ELANE (0.54) MAPTCYP1A2CYP2C9CYP2C19PRNP
SCHEMBL16039806 0.86 POLB (0.55) MAPTCYP1A2CYP2C9CYP2C19L3MBTL1
SCHEMBL4121482 0.83 POLB (0.56) MAPTCYP1A2CYP2C9CYP2C19L3MBTL1
SCHEMBL16504846 0.82 KDM4E (0.53) MAPTCYP1A2CYP2C9CYP2C19L3MBTL1
SCHEMBL16039558 0.82 CYP19A1 (0.47) MAPTCYP1A2CYP2C9CYP2C19PRNP
SCHEMBL10750689 0.80 ALDH1A1 (0.60) MAPTCYP1A2CYP2C9CYP2C19PRNP
SCHEMBL4104005 0.79 TSPO (0.57) MAPTCYP1A2CYP2C9CYP2C19PRNP
SCHEMBL31437231 0.79 KDM4E (0.59) MAPTCYP1A2CYP2C9CYP2C19L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4711890-A TREATMENT OF ANXIETY STATES OR OF PULMONARY, RENAL, CIRCULATORY OF CARDIOVASCULAR DISORDERS RHONE-POULENC SANTE (FR) 1987-12-08 US disclosed
US-4684652-A TREATING ANXIETY OR CARDIOVASCULAR DISORDERS RHONE-POULENC SANTE (FR) 1987-08-04 US disclosed