SCHEMBL10757

SCHEMBL10757

Brc1ccc2[nH]cnc2c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 1/20 0.52
PIM1 P11309 1/20 0.52
AKT1 P31749 1/20 0.52
FLT3 P36888 1/20 0.52
PIM3 Q86V86 1/20 0.52
MAPT P10636 4/20 0.47
KDM4E B2RXH2 2/20 0.47
ALDH1A1 P00352 2/20 0.47
APEX1 P27695 1/20 0.47
RECQL P46063 1/20 0.47
BLM P54132 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
FBP1 P09467 1/20 0.46
EPHB2 P29323 1/20 0.46
MKNK1 Q9BUB5 1/20 0.46
QPCT Q16769 1/20 0.45
PRKCI P41743 1/20 0.44
RAD52 P43351 1/20 0.42
CYP2A6 P11509 1/20 0.42
AHR P35869 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29908911 1.00 CHEK1 (0.52) CHEK1PIM1AKT1FLT3PIM3
Benzimidazole SCHEMBL26920544 0.91 CHEK1 (0.45) CHEK1PIM1AKT1FLT3PIM3
SCHEMBL20514058 0.89 CHEK1 (0.47) CHEK1PIM1AKT1FLT3PIM3
SCHEMBL29467513 0.83 PRKCI (0.59) CHEK1PIM1AKT1FLT3PIM3
SCHEMBL110207 0.83 PRKCI (0.59) CHEK1PIM1AKT1FLT3PIM3
Hydrochloric Acid SCHEMBL16011437 0.81 KDM4E (0.60) CHEK1PIM1AKT1FLT3PIM3
SCHEMBL28178103 0.80 IDO1 (0.50) CHEK1PIM1AKT1FLT3PIM3
SCHEMBL28076068 0.79 QPCT (0.41) CHEK1PIM1AKT1FLT3PIM3
SCHEMBL6008269 0.77 MAPT (0.50) MAPTKDM4EALDH1A1APEX1RECQL
SCHEMBL31143361 0.77 MAPT (0.50) MAPTKDM4EALDH1A1APEX1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 596 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260109670-A1 METHOD FOR ARYL DEBROMINATION AND ACYLATION OF BROMINATED BENZO-FUSED NITROGEN HETEROCYCLE Shanghai OuChem Bio-Technology Co., LTD (CN) 2026-04-23 US claimed
CN-119661511-A Benzimidazole compound and application thereof 山东农业大学 2025-03-21 CN claimed
CN-118581738-A Preparation method of patterned local super-hydrophobic breathable cotton fabric based on ink-jet printing technology 青岛大学 2024-09-03 CN claimed
CN-116143414-B Preparation method of vitrified ZIF-300 material 天津工业大学 2024-08-09 CN claimed
CN-118344611-A Method for preparing micro-nano metal organic framework by oil-water two-phase method and application 广西师范大学 2024-07-16 CN claimed
EP-4397399-A2 MEMBRANES COMPRISING A LAYER OF METAL ORGANIC FRAMEWORK PARTICLES G2O Water Technologies Limited (GB) 2024-07-10 EP claimed
CN-117254210-A Composite diaphragm, preparation method thereof, electrochemical device and electricity utilization device 中材锂膜有限公司 2023-12-19 CN claimed
CN-116574293-B Dampproof heat-preserving PE bubble film and preparation method thereof 珠海嘉雄包装材料有限公司 2023-11-28 CN claimed
CN-116574293-A Dampproof heat-preserving PE bubble film and preparation method thereof 珠海嘉雄包装材料有限公司 2023-08-11 CN claimed
CN-116143414-A Preparation method of vitrified ZIF-300 material 天津工业大学 2023-05-23 CN claimed
EP-3774001-A1 MEMBRANES COMPRISING A LAYER OF METAL ORGANIC FRAMEWORK PARTICLES G2O Water Technologies Limited (GB) 2021-02-17 EP claimed
US-20210016232-A1 MEMBRANES COMPRISING A LAYER OF METAL ORGANIC FRAMEWORK PARTICLES EVOVE LTD (GB) 2021-01-21 US claimed
CN-107955020-B Method for synthesizing benzimidazol oxazinone compound by copper salt catalysis in one pot 西南大学 2020-09-22 CN claimed
CN-111253580-A Preparation method of tubular MOF (Metal organic framework) membrane 中国科学院大连化学物理研究所 2020-06-09 CN claimed
CN-110003187-A Polyfluoroalkyl substituted benzofuran compound and preparation method thereof 南京工业大学 2019-07-12 CN claimed
US-10086331-B2 Carbon dioxide capture using phase change ionic liquids UNIVERSITY OF NOTRE DAME DU LAC (US) 2018-10-02 US claimed
US-20160288051-A1 CARBON DIOXIDE CAPTURE USING PHASE CHANGE IONIC LIQUIDS UNIVERSITY OF NOTRE DAME DU LAC (US) 2016-10-06 US claimed
CN-103446893-B Method for preparing metal organic framework membrane on inner wall of tubular ceramic support NANJING TECH UNIVERSITY (CN) 2015-09-02 CN claimed
WO-2011033235-A1 COMPOSITE MATERIAL COMPRISING AN ORGANIC-INORGANIC MATERIAL, PREPARATION PROCESS, AND USES TREDI (FR) 2011-03-24 WO claimed
US-4105656-A PROCESS FOR PREPARING 3-N-MONOSUBSTITUTED AMINO-4-SUBSTITUTED-5-PYRAZOLONES FUJI PHOTO FILM CO., LTD. (JP) 1978-08-08 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260109670-A1 METHOD FOR ARYL DEBROMINATION AND ACYLATION OF BROMINATED BENZO-FUSED NITROGEN HETEROCYCLE NAT1, AADAC, NAA15 CHEK1 276/4885PIM1 855/4885AKT1 3215/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.