Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 7/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7495845 | 0.90 | TOP2A (0.38) | KCNH2HRH3TOP2ATOP2BALDH1A1 | |
| SCHEMBL7498379 | 0.90 | KCNH2 (0.46) | KCNH2HRH3TOP2ATOP2BALDH1A1 | |
| SCHEMBL6213672 | 0.83 | KCNH2 (0.36) | KCNH2HRH3TOP2ATOP2BALDH1A1 | |
| SCHEMBL9416465 | 0.82 | TOP2A (0.42) | KCNH2TOP2ATOP2BALDH1A1KDM4E | |
| SCHEMBL6217185 | 0.82 | KDM4E (0.50) | TOP2ATOP2BALDH1A1KDM4ELMNA | |
| SCHEMBL9501126 | 0.81 | KDM4E (0.56) | KCNH2HRH3TOP2ATOP2BALDH1A1 | |
| SCHEMBL6216986 | 0.81 | MEN1 (0.46) | KCNH2TOP2ATOP2BGSK3BMEN1 | |
| SCHEMBL9501339 | 0.81 | KCNH2 (0.55) | KCNH2HRH3TOP2ATOP2BALDH1A1 | |
| SCHEMBL10683412 | 0.81 | KCNH2 (0.47) | KCNH2HRH3TOP2ATOP2BALDH1A1 | |
| SCHEMBL9502044 | 0.81 | KCNH2 (0.52) | KCNH2HRH3TOP2ATOP2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230274-A2 | Derivatives of 7-(azabicycloalkyl)-quinoloncarboxylic acid and -naphthyridoncarboxylic acid | BAYER AG (DE) | 1987-07-29 | — | — | EP | disclosed |