Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10758567 | 0.92 | HPGD (0.51) | HPGDALDH1A1KDM4EKMT2AL3MBTL1 | |
| SCHEMBL10758800 | 0.82 | LTA4H (0.51) | ALDH1A1KDM4EKMT2AL3MBTL1MAPK1 | |
| SCHEMBL5457081 | 0.81 | MAPT (0.52) | ALDH1A1KDM4EL3MBTL1MAPK1LMNA | |
| SCHEMBL11675736 | 0.80 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1LMNATDP1SMN1; SMN2 | |
| SCHEMBL5450104 | 0.80 | FFAR1 (0.52) | ALDH1A1L3MBTL1MAPK1LMNARORC | |
| SCHEMBL10759781 | 0.80 | MAPK1 (0.46) | HPGDALDH1A1KDM4EKMT2AL3MBTL1 | |
| SCHEMBL10754330 | 0.79 | TDP1 (0.46) | ALDH1A1KMT2AL3MBTL1CYP4F2CYP4A11 | |
| SCHEMBL10759014 | 0.78 | LMNA (0.48) | HPGDALDH1A1KDM4EKMT2AL3MBTL1 | |
| SCHEMBL3105018 | 0.77 | LTA4H (0.52) | HPGDALDH1A1KDM4EKMT2AL3MBTL1 | |
| SCHEMBL10759566 | 0.77 | SPHK1 (0.41) | ALDH1A1KDM4EL3MBTL1LMNARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4672071-A | Antihypertensive dihydropyridine compositions, optical isomers and intermediates | SYNTEX (U.S.A.) INC. (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0191448-A2 | Antihypertensive dihydropyridine derivatives | SYNTEX (U.S.A.) INC. (US) | 1986-08-20 | — | — | EP | disclosed |
| US-4595690-A | Hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1986-06-17 | — | — | US | disclosed |