Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | TYMP | P19971 | 14/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10758609 | 1.00 | PDE4D (0.38) | PDE4DTYMPPSEN1PSEN2APH1B | |
| SCHEMBL10423649 | 0.91 | PDE4D (0.38) | PDE4DTYMPPSEN1PSEN2APH1B | |
| SCHEMBL10423648 | 0.91 | PDE4D (0.38) | PDE4DTYMPPSEN1PSEN2APH1B | |
| SCHEMBL19891704 | 0.85 | PDE4D (0.49) | PDE4DPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10423644 | 0.85 | TYMP (0.38) | PDE4DTYMPPSEN1PSEN2APH1B | |
| SCHEMBL10423643 | 0.85 | TYMP (0.38) | PDE4DTYMPPSEN1PSEN2APH1B | |
| SCHEMBL9307935 | 0.83 | TYMP (0.41) | TYMP | |
| SCHEMBL1776371 | 0.83 | PDE4D (0.51) | PDE4DPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10755806 | 0.83 | PDE4D (0.51) | PDE4DPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9307929 | 0.83 | TYMP (0.41) | TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4683314-A | ANTICHOLESTEROL | MERCK & CO., INC. (US) | 1987-07-28 | — | — | US | disclosed |
| US-4540796-A | PREPARATION OF 4-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONE DERIVATIVE | MERCK & CO., INC. (US) | 1985-09-10 | — | — | US | disclosed |
| US-4440927-A | Process for preparing inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase via a chiral synthon | MERCK & CO., INC. (US) | 1984-04-03 | — | — | US | disclosed |