Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16525868 | 0.79 | NOTUM (0.33) | NOTUMMEN1NPC1POLBMAPT | |
| SCHEMBL16264090 | 0.76 | AR (0.35) | NOTUMKMT2ADPP8AR | |
| SCHEMBL10754980 | 0.76 | AADAT (0.38) | NOTUMMEN1NPC1POLBMAPT | |
| SCHEMBL19954697 | 0.73 | NOTUM (0.42) | NOTUMHPGDMTNR1ASLC6A2MTNR1B | |
| SCHEMBL22005465 | 0.73 | ROCK1 (0.51) | NOTUMHPGDNPC1POLBMAPT | |
| SCHEMBL7075121 | 0.73 | ROCK1 (0.51) | NOTUMHPGDNPC1POLBMAPT | |
| SCHEMBL11445560 | 0.73 | NOTUM (0.42) | NOTUMHPGDMTNR1ASLC6A2 | |
| SCHEMBL22923714 | 0.73 | NOTUM (0.42) | NOTUMHPGDMTNR1ASLC6A2MTNR1B | |
| SCHEMBL18707381 | 0.73 | NOTUM (0.42) | NOTUMHPGDMTNR1ASLC6A2MTNR1B | |
| SCHEMBL17652443 | 0.72 | MTNR1A (0.40) | MTNR1APOLBMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4659731-A | 2-(4,5-Dihydro-1H-imidazol-2-yl)-2,3-dihydroindole derivatives and their application as α2 receptor antagonist or α1 receptor agonists | SYNTHELABO (FR) | 1987-04-21 | — | — | US | disclosed |