Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HK1 | P19367 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | GALK1 | P51570 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | HTR2C | P28335 | 4/20 | 0.37 |
| ▸ | QPCT | Q16769 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10761116 | 0.82 | BRD4 (0.44) | KDM4ENPC1MAPTBRD4CREBBP | |
| SCHEMBL9851803 | 0.73 | CREBBP (0.39) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL2421457 | 0.73 | KDM4E (0.49) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL10830879 | 0.70 | HTR2A (0.50) | KDM4ENPC1RAB9AHTR2AHTR2C | |
| SCHEMBL11484490 | 0.69 | NPC1 (0.42) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL4135918 | 0.68 | CREBBP (0.46) | BRD4CREBBP | |
| SCHEMBL10830706 | 0.66 | HTR2A (0.41) | NPC1RAB9AKMT2AMAPTBRD4 | |
| SCHEMBL9851810 | 0.66 | CHRM1 (0.44) | PKMSMN1; SMN2 | |
| SCHEMBL20777927 | 0.66 | PIM1 (0.39) | KMT2ABRD4CREBBPHTR2AHTR2C | |
| SCHEMBL3201336 | 0.65 | PIM1 (0.44) | KDM4EKMT2AMEN1MAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4678784-A | LUTEINIZING HORMONE RELEASING HORMONE | MCNEILAB, INC. (US) | 1987-07-07 | — | — | US | disclosed |
| EP-0219292-A2 | Use of indolobenzodiazepines for antagonizing luteinizing hormone releasing hormone | McNeilab, Inc. (US) | 1987-04-22 | — | — | EP | disclosed |
| US-4587244-A | Amidine benzodiazepines, methods for their use and intermediates | MCNEILAB, INC. (US) | 1986-05-06 | — | — | US | disclosed |
| US-4547497-A | Amidine benzodiazepines, methods for their use and intermediates | MCNEILAB, INC. (US) | 1985-10-15 | — | — | US | disclosed |