Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 11/20 | 0.46 |
| ▸ | BRD4 | O60885 | 9/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9851805 | 0.85 | CNR1 (0.44) | CREBBPBRD4GABRA1GABRG2GABRB3 | |
| SCHEMBL9851803 | 0.82 | CREBBP (0.39) | CREBBPBRD4HTR1ACCNB2CDK1 | |
| SCHEMBL20777927 | 0.81 | PIM1 (0.39) | CREBBPBRD4HTR1AL3MBTL1MAOB | |
| SCHEMBL10761116 | 0.73 | BRD4 (0.44) | CREBBPBRD4 | |
| SCHEMBL3690376 | 0.70 | CREBBP (0.32) | CREBBPBRD4HTR1AMAOAMAOB | |
| SCHEMBL6697572 | 0.69 | NOTUM (0.40) | HTR1AL3MBTL1 | |
| SCHEMBL9851810 | 0.69 | CHRM1 (0.44) | — | |
| SCHEMBL9851860 | 0.69 | CDK1 (0.44) | CREBBPBRD4CCNB2CDK1CCNB1 | |
| SCHEMBL9851857 | 0.69 | GSK3B (0.40) | CREBBPCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL17073536 | 0.68 | AKT1 (0.44) | CREBBPBRD4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090136449-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-05-28 | — | — | US | disclosed |
| EP-0406719-A1 | 4h-indolo(1,2-d)(1,2,4)triazolo (4,3-a)(1,4)benzodiazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-09 | — | — | EP | disclosed |
| US-4914201-A | CHEMICAL INTERMEDIATES FOR ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-04-03 | — | — | US | disclosed |
| US-4897392-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090136449-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | IDO1, IDO2, ZC3HAV1 | CREBBP 2995/4885BRD4 468/4885HTR1A 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.