Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 6/20 | 0.39 |
| ▸ | BRD4 | O60885 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | HTR2C | P28335 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HK1 | P19367 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9851810 | 0.85 | CHRM1 (0.44) | ALDH1A1ALOX12SMN1; SMN2 | |
| SCHEMBL4135918 | 0.82 | CREBBP (0.46) | CREBBPBRD4HTR1ACCNB2CDK1 | |
| SCHEMBL10763517 | 0.73 | KDM4E (0.38) | CREBBPBRD4KMT2AKDM4EMEN1 | |
| SCHEMBL2421457 | 0.73 | KDM4E (0.49) | KMT2AKDM4EMEN1MAPTRECQL | |
| SCHEMBL9851805 | 0.69 | CNR1 (0.44) | CREBBPBRD4KMT2AMEN1MAPT | |
| SCHEMBL9851806 | 0.69 | HTR2A (0.40) | KMT2AKDM4EMEN1MAPTRECQL | |
| SCHEMBL17073536 | 0.68 | AKT1 (0.44) | CREBBPBRD4KMT2AKDM4EMEN1 | |
| SCHEMBL10761116 | 0.68 | BRD4 (0.44) | CREBBPBRD4KDM4EMAPTHPGD | |
| SCHEMBL20777927 | 0.66 | PIM1 (0.39) | CREBBPBRD4KMT2AHTR2AHTR2C | |
| SCHEMBL3690376 | 0.64 | CREBBP (0.32) | CREBBPBRD4KMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4914201-A | CHEMICAL INTERMEDIATES FOR ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-04-03 | — | — | US | claimed |
| EP-0406719-A1 | 4h-indolo(1,2-d)(1,2,4)triazolo (4,3-a)(1,4)benzodiazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-09 | — | — | EP | disclosed |
| US-4914201-A | CHEMICAL INTERMEDIATES FOR ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-04-03 | — | — | US | disclosed |
| US-4914201-A | CHEMICAL INTERMEDIATES FOR ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-04-03 | — | — | US | disclosed |
| US-4897392-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | disclosed |