Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 11/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9851803 | 0.85 | CREBBP (0.39) | ALDH1A1ALOX12SMN1; SMN2 | |
| SCHEMBL9851805 | 0.85 | CNR1 (0.44) | DRD3TGM2CES1CNR1NTSR1 | |
| SCHEMBL17522841 | 0.70 | PIK3CA (0.41) | NPSR1DRD3DRD2DRD4 | |
| SCHEMBL4135918 | 0.69 | CREBBP (0.46) | — | |
| SCHEMBL10416848 | 0.68 | OPRK1 (0.51) | DRD3CNR1OPRK1PDE4D | |
| SCHEMBL11686737 | 0.66 | MEN1 (0.50) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL10763517 | 0.66 | KDM4E (0.38) | PKMSMN1; SMN2 | |
| SCHEMBL9851851 | 0.65 | BRD4 (0.52) | ALDH1A1SMN1; SMN2DRD3CNR1OPRK1 | |
| SCHEMBL9851806 | 0.64 | HTR2A (0.40) | CHRM1ALDH1A1PKMHTTNPSR1 | |
| SCHEMBL9269071 | 0.63 | TGM2 (0.42) | CHRM1ALDH1A1PKMHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4914201-A | CHEMICAL INTERMEDIATES FOR ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-04-03 | — | — | US | claimed |
| EP-0406719-A1 | 4h-indolo(1,2-d)(1,2,4)triazolo (4,3-a)(1,4)benzodiazepines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-09 | — | — | EP | disclosed |
| US-4914201-A | CHEMICAL INTERMEDIATES FOR ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-04-03 | — | — | US | disclosed |
| US-4897392-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-01-30 | — | — | US | disclosed |