Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1075786 | 0.87 | BACE1 (0.58) | BACE1KCNH2 | |
| SCHEMBL946602 | 0.80 | BACE1 (0.57) | BACE1KCNH2 | |
| SCHEMBL946784 | 0.75 | BACE1 (0.76) | BACE1KCNH2 | |
| SCHEMBL1076368 | 0.71 | BACE1 (0.43) | BACE1KCNH2 | |
| SCHEMBL1075789 | 0.66 | BACE1 (0.74) | BACE1KCNH2 | |
| SCHEMBL946600 | 0.65 | TTK (0.33) | — | |
| SCHEMBL946110 | 0.64 | BACE1 (0.50) | BACE1KCNH2ALOX5APFEN1 | |
| SCHEMBL943489 | 0.61 | BACE1 (1.00) | BACE1KCNH2 | |
| SCHEMBL13385087 | 0.59 | PDE4B (0.48) | ALOX5APFEN1 | |
| SCHEMBL3791228 | 0.59 | ALDH1A1 (0.56) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |