Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD3 | Q15059 | 1/20 | 0.55 |
| ▸ | RB1 | P06400 | 7/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10764787 | 1.00 | BRD3 (0.55) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL1200756 | 0.84 | BRD3 (0.57) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL13751063 | 0.79 | BRD3 (0.61) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL6924595 | 0.77 | GRIN2B (0.59) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL13751061 | 0.75 | BRD3 (0.56) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL832934 | 0.75 | SIRT1 (0.60) | BRD3RB1SIRT1SIRT2CYP2D6 | |
| SCHEMBL18085037 | 0.75 | BRD3 (0.56) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL1877922 | 0.74 | BRD3 (0.67) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL12159018 | 0.74 | BRD3 (0.55) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL10754574 | 0.74 | BRD3 (0.55) | BRD3RB1SIRT1SIRT2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4698351-A | Tetrahydrocarbazole derivatives and pharmaceutical compositions | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1987-10-06 | — | — | US | disclosed |
| US-4618614-A | Method of treating psychosis using tetrahydrocarbazole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-21 | — | — | US | disclosed |
| US-4547576-A | Tetrahydrocarbazole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-10-15 | — | — | US | disclosed |